Review Article

Interdictory contribution of Vitamin D to prevent corona virus infections

Neelam Lahari*, Vinoy K Shrivastava, Arathi Sreenikethanam, Subhisha Raj and Amit K Bajhaiya*

Published: 16 November, 2022 | Volume 6 - Issue 1 | Pages: 073-081

The impact of vitamin D on the musculoskeletal system is well known. The diverse role of vitamin D is well supported by the functionality of vitamin D receptors and vitamin D activating enzymes (hydroxylase) present in tissues and cells. Hypovitaminosis D causes rickets, osteomalacia, hyperparathyroidism, and an increased risk of bone fracture. Vitamin D has immune-stimulatory effects on both the innate and adaptive immune systems. Vitamin D induces antimicrobial peptide cathelicidin and defensin that can inhibit viral replication of pro-inflammatory cytokines that regulate inflammatory encasement. Moreover, several studies on vitamin D have shown its interdictory role in the immune and respiratory systems. This global crisis, the COVID-19 pandemic condition has increased the risk of acute respiratory tract infection by immune dysregulation along with cytokine storm, which further progress into acute respiratory distress syndrome. Vitamin D has immunomodulatory and anti-inflammatory properties which are effective against respiratory viral infections. Vitamin D supplementation has shown a compatible effect on viral infection. This review article discusses the role of vitamin D in reducing the risk of respiratory infections including the severity of COVID-19 infections. This review focuses on the therapeutic role of vitamin D to improve clinical outcome during COVID-19 infection and suggest its possible role in the prevention and treatment of respiratory infections.

Read Full Article HTML DOI: 10.29328/journal.afns.1001041 Cite this Article Read Full Article PDF


Vitamin D; COVID-19; Respiratory infection; Immune system; Hypovitaminosis D; Vitamin D receptor


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